Wound Healing, Oral & Topical Activity Of Aloe Vera
Davis RH; Leitner MG; Russo JM; Byrne ME
J Am Podiatr Med Assoc Vol 79, Number 11, Nov 1989, P559-62

The influence of Aloe vera, orally and topically, on wound healing was studied. Wounds were induced on both sides of the vertebral column of ICR mice using a biopsy punch. For the oral study, experimental animals received A. vera in their drinking water for 2 months, whereas the control animals received only water. In the topical study, experimental animals were given 25% A. vera in Eucerin cream topically. The control animals received cream only. A 62.5% reduction in wound diameter was noted in mice receiving 100 mg/kg/day oral A. vera and a 50.8% reduction was recorded in animals receiving topical 25% A. vera. These data suggest that A. vera is effective by both oral and topical routes of administration.

Anti-Inflammatory & Wound Healing Activity Of A Growth Substance In Aloe Vera
Davis RH; Donato JJ; Hartman GM; Haas RC
Department Of Biomedical Sciences, Pennsylvania College Of Podiatric Medicine
J Am Podiatr Med Assoc 84(2):77-81 1994 Feb

Aloe vera improves wound healing and inhibits inflammation. Since mannose-6-phosphate is the major sugar in the Aloe gel, the authors examined the possibility of its being an active growth substance. Mice receiving 300 mg/kg of mannose-6-phosphate had improved wound healing over saline controls. This dose also had anti-inflammatory activity. The function of mannose-6-phosphate in A. vera is discussed.

Aloe Vera, Hydrocortisone, & Sterol Influence On Wound Tensile Strength & Anti-Inflammation
Davis RH; DiDonato JJ; Johnson RW; Stewart CB
Pennsylvania College Of Podiatric Medicine
J Am Podiatr Med Assoc 84(12):614-21 1994 Dec

Aloe vera at doses of 100 and 300 mg/kg daily for 4 days blocked the wound healing suppression of hydrocortisone acetate up to 100% using the wound tensile strength assay. This response was because of the growth factors present in A. vera masking the wound healing inhibitors such as sterols and certain amino acids. The sterols showed good anti-inflammatory activity (-36%) in reducing the croton oil-induced ear swelling. This activity displayed a dose-response relationship.

Beneficial Effects Of Aloe In Wound Healing
Heggers JP; Pelley RP; Robson MC
Department Of Surgery & Graduate School Of Biomedical Sciences, University Of Texas Medical Branch
Phytotherapy Research (1993) Vol 7, No. Special issue, pp. S48-S52. 10 pl. (5 col. pl.). 17 ref.

The therapeutic effects of A. vera [A. babadensis] were examined in preventing progressive dermal ischaemia caused by burns, frostbite, electrical injury, distal dying flap and intra-arterial drug abuse in man and animal models. In vivo analysis of these injuries showed that the mediator of progressive tissue damage was thromboxane A2 (TxA2). Experimentally, A. vera was compared to a variety of antithromboxane agents (U38450, a lodoxamide, a lazaroid and an Aloe wound gel). In the burn injury, A. vera was comparable to the lodoxamide and lazaroid with an 82% to 85% tissue survival when compared with the control and the Aloe wound gel. Tissue survival in the experimental frostbite injury was 28.2% when compared with the control. Similar results were obtained for the electrical injury, and intra-arterial drug abuse. Clinically burn patients treated with A. vera healed without tissue loss as did those with frostbite. In the intra-arterial drug abuse patients, A. vera reversed tissue necrosis. This therapeutic approach was used to prevent progressive tissue loss in each injury by actively inhibiting the localized production of TxA2. A. vera not only acts as a TxA2 inhibitor but maintains a homeostasis within the vascular endothelium as well as the surrounding tissue.