Immunostimulant Properties Of An Extract Isolated & Partially Purified From Aloe Vahombe
Solar S; Zeller H; Rasolofonirina N; Coulanges P; Ralamboranto L; Andriatsimahavandy AA; Rakotovao LH; Le Deaut JY
Arch Inst Pasteur Madagascar 47(1):9-39 1980

When the mice are given a hypodermic infection of unrefined Vahombe extract, the Aloe called Vahombe is a liliaceous plant growing in the South of Madagascar, they are protected against the infection caused by the Klebsiella, a pneumonia vector to man, giving rise to an experimental septicaemia in the mouse. Neither bactericide nor bacteriostatic activity has been detected yet about Aloe extract. The anti-infectious activity is proportional to the dose of extract injected, the protecting power is the greatest when the mice have been treated with Aloe, two or three days previously to the infection due to Klebsiella pneumoniae. We have determined the LD50 (Lethal dose 50) for the check batches (non-treated mice) and for the batches of protected mice. We were able to show that the previous injection developed the resistance to infection, multiplied from thirtyfold to a hundredfold. We have tackled the purification of the substance—made soluble after lyophilisation of the crude extract—by means of filtration with Sephadex G50. It would be the first time, for all we know, that a substance endowed with organism. At present we are proceeding with the purification of the active principle and contemplating trying the protective power upon virus infections as well as upon cancerous or parasitic ones.

Aloe Vera: Its Potential Use in Wound Healing & Disease Control in Oral Conditions
Moore, Timothy E

Aloe vera has been shown to enhance defense mechanisms, and it has a variety of components to help combat periodontal disease and other oral conditions. As a periodontist utilizing Aloe vera in various consistencies for the last 14 years with over 6,000 documented patients who have been treated with applications, I’ve observed remarkable healing, reduced edema, and pain control. There are eight main uses of Aloe vera in dental practice:

1. Applications directly to the sites of periodontal surgery.
2. Applications to the gum tissues when they have been traumatized or scratched by toothbrush-dentifrice abrasion, sharp foods, dental floss, and toothpick injuries.
3. Chemical burns are relieved quickly from accidents with aspirin.
4. Extraction sites respond more comfortably and dry sockets do not develop when Aloe vera is applied.
5. Acute mouth lesions are improved by direct application on herpetic viral lesions, aphthous ulcers, canker sores, and cracks occuring at the corners of our lips. Gum abscesses are soothed by the applications as well.
6. Other oral diseases chronic in nature respond with Lichen Planus and Benign Pemphigus. Even gum problems associated with AIDS and Leukemia patients receive relief. Migratory glossititis, geographic tongue and Burning Mouth Syndrome are improved.
7. Denture patients with sore ridges and ill-fitting dentures and partials can benefit as fungises and bacterial contamination reduce the inflammatory irritations.
8. Aloe vera can also be used around dental implants to control inflammation from bacteria contamination.

Other oral disorders such as Candidiasis, Desquamative Gingivitis, Vesiculobullous diseases, acute monocytic leukemia, hematological disorders and nutritional problems all respond to Aloe vera use. Even diabetes mellitus, Sjorgen’s Syndrome, menopausal patients and medications which can cause Xerostomia or dry mouth. Interest is gathering momentum across our country as researchers are becoming interested in alternative therapy utilizing natural products versus synthetic agents. Aloe vera research is currently being undertaken at Oklahoma University, Baylor University, and Loma Linda. Lastly, it was a privilege to use Aloe vera on the bombing victims in the April 1995 disaster in Oklahoma City. The attendants, doctors and especially the injured learned that the healing capabilities of Aloe vera far exceeded their expectations in pain control and healing time reduction. Aloe vera has an unlimited future in new applications, and I sense in dentistry we are just on the cutting edge of promising utilization for anti-inflammatory procedure, antiviral, and immunological benefits for our patients.

Effect Of Aloe Vera On Herpes Simplex & Herpes Virus (Strain Zoster)
Sims, Ruth J; Zimmermann ER

In 1970 Simms and Zimmermann performed a series of tests to determine the bactericidal potentials of Aloe vera. In testing the effect of Aloe vera gel on mycotic organisms (fungi), Sims and Zimmermann found that Aloe vera gel in percentages of 80% to 90% killed Tinea pedia (a causal agent in athlete’s foot) and Tinea ungium (a causal agent in ringworm of the nails)each in about five hours time. Later, in the same year, Sims and Zimmermann tested the cytopathology of Aloe vera gel against 100 tissue cultures of both herpes simplex and herpes zoster strains of virus. The test, conducted on primary hamster kidney cultures, showed that in all 100 tissue doses Aloe vera provided virucidal against both strains within 72 hours.

Aloe Vera Gel Toothpaste
King, Ronald M; Carroll Thomas F
U.S., 6 pp. Cont.-in-part of U.S. Ser. No. 791,408, abandoned

A toothpaste compn. contains a dentifrice base which includes at least a detergent, an abrasive or polishing agent, and mixt. of Aloe vera and chlorophyll. The toothpaste compn. is useful in preventing gingivitis, controlling plaque, and stimulating the growth of new tissue while reducing the hazards of bacterial contamination. Thus, a dentifrice contained 25% oil of wintergreen soln. 90.0 mg, sorbitol 9.0, SDS 30.0, CaHPO4 30.0, glycerin 37.5, water 100.0, carrageenan 7.5, CaCO3 60.0, Aloe vera gel 50 g, and Cu chlorophyllin (50 mg/cm3) 250 mg. Use of this toothpaste for 10-14 days reduced the bleeding point in patients with gingivitis.