A Study By Dr. Terry Pulse, M.D. Of 29 AIDS Patients
Journal of Advancement in Medicine Winter 1990, Volume 3, No. 4

Patients took 1200 mg of the active ingredient in Aloe vera juice daily as well as nutrient supplements. We quote directly from Dr. Pulse’s report of the results, which are fantastic: “No adverse effects attributable to the essential fatty acid capsules were observed nor any side effects of the nutritional supplementation powder nor of the Aloe vera juice. Most patients who were symptomatic reported that within three to five days their energy levels improved, fever disappeared, night sweats stopped, cough decreased or stopped altogether, shortness of breath decreased, lymph nodes decreased in size, diarrhea stopped, strength improved and the only measurable side effect of this particular study was weight gain, which is a desirable effect. There were no biochemical abnormalities noted on MAC in this particular study. AZT induced anemia improved on this particular regimen. Chest x-rays remained normal throughout the study. No changes in EKG from baseline were observed. There was great improvement in all patients to hypersensitivity skin testing at the end of 90 days... Not only did the patients improve clinically and functionally, but their Karnofsky scores improved in 93.1% of the patients at 90 days and in 100% at 180 days. 51.7% of the patient’s T4 helper lymphocytes increased at 90 days and 32.2% at 180 days, with 25% reactive HIV P24 core antigen converted to negative at 90 days and 180 days.”

In essence, a substantial number of patient’s physical condition improved. Energy levels improved, fever disappeared, night sweats stopped, cough decreased or stopped, shortness of breath decreased, lymph nodes decreased in size, diarrhea stopped, weakness improved. Hypersensitivity skin testing improved. In 96.4% of the test patients, their Modified Walter Reed Scores had improved at 180 days. Karnofsky scores improved in 93.1%. T4 lymphocytes increased in some patients and, in some, their reactive HIV P24 antigen converted to negative.

Substance Boosts Therapeutic Effects Of AZT
Texas A & M University
Aids Weekly August 5, 1991 p2(2)

A team of scientists from Texas A&M University, College Station, and three other institutions says that a complex carbohydrate compound purified from the Aloe vera plant appears to help drugs such as azidothymidine (AZT) and acyclovir (ACY) block the pathology associated with HIV and herpes simplex virus (HSV). They also found that the compound interfered with HIV’s ability to reproduce in infected cells. “It’s not going to be a magic bullet against AIDS,” cautions Dr. Maurice C. Kemp, a virologist in Texas A&M’s College of Veterinary Medicine. “There aren’t many magic bullets out there. But as an adjunctive therapy, it looks like it can be used in combination with other therapies.” The scientists’ findings are published in the July, 1991, issue of the new Journal Molecular Biotherapy with additional results scheduled to be published in the September, 1991, issue.

Aloe Vera May Mimic AZT Without Toxicity
McDaniel, H Reginald
Medical World News December 1993

A preliminary study suggests that the Aloe vera may mimic AZT without toxicity. A substance in Aloe vera show signs of boosting the immune systems of AIDS patients and blocking the human immune-deficiency virus spread without the toxic side effects.

Mechanisms Of Ultraviolet Induced Immune Suppression
Strickland FM
UT MD Anderson Cancer Center
Crisp Data Base National Institutes Of Health

RPROJ/CRISP Epicutaneous exposer to ultraviolet (UV) radiation suppresses T cell-mediated immune responses to antigens encountered in the skin and permits the growth of highly immunogenic skin cancers in laboratory animals. Immune suppression by UV radiation is mediated by multiple, complex, and interacting mechanisms. Recent studies indicate the suppression is triggered by DNA damage followed by production of immunosuppressive cytokines, loss of antigen presenting cells (APC) from the skin, alteration of the functions of remaining APC, and induction of antigen-specific suppressor T cells. However, the regulation and interaction of these APC, and induction of antigen-specific suppressor T cells. However, the regulation and interaction of these APC and cytokine pathways are unclear and appears to be different for contact hypersensitivity (CHS) reactions to allergens in skin and delayed type hypersensitivity (DTH) reactions to micro-organisms. We have recently shown that crude extracts of Aloe barbadensis gel protects CHS and DTH responses against suppression by UV radiation. Because Aloe extract provides broad protection for immune responses that are abrogated by UN by different mechanisms, it may act as a central controlling point in suppression. Alternatively Aloe may contain several agents that act on CHS and DTH separately. Furthermore, Aloe is chemically distinct from antibodies, cytokines, or other agents that have been used to probe suppression pathway induced by UV radiation, and it may be acting by a novel mechanism(s). We will test these hypotheses by exposing mice to UV radiation and examining the effect of Aloe treatment on the production of the regulatory cytokines TNF-alpha, IL-10, and Il-12 in cultured keratinocyte cell liens and in skin. We will investigate whether protection of CHS and DTH responses is mediated separately by different components in Aloe. We will also examine the effect of Aloe on the function of APC from the draining lymph nodes using the murine model of CHS response to the hapten fluorescein isothiocyanate, and the DTH response to Candida albicans. In addition, we propose to investigate the ability of Aloe to preserve immunity to UV-induced skin cancers. Clarification of the relationship of the CHS and DTH models to cutaneous tumor immunity may permit the design of therapeutic agents that are more effective in protecting humans against the development of skin cancer.

Immunomodulating Properties Of An Extract Isolated & Partially Purified From Aloe Vahombe Study Of Antitumoral Properties & Contribution To The Chemical Nature & Active Principle
Ralamboranto L; Rakotovao LH; Le Deaut JY; Chaussoux D; Salomon JC; Fournet B; Montreuil J; Rakotonirina-Randriambeloma PJ; Dulat C; Coulanges P
Arch Inst Pasteur Madagascar 50(1):227-56 1982

An immuno-modulator fraction (Alva) extracted from an endemic plant, in the south of Madagascar, the Aloe vahombe, significantly protects mice against bacterial, parasitic and fungal infections. Wishing to verify whether the fraction Alva was active in tumour reduction, we studied its effect on the development of experimental fibrosarcoma and melanoma in mice by intravenous and intracutaneous injections and injections directly into the tumor of the immunostimulant fraction. We have observed cures, only in the case of the McC3-1 tumor but it is encouraging to note that under different experimental conditions the rate of growth of tumors in animals which were treated is slower than in those not treated. The Alva fraction is a substance which is hydrosoluble, thermostabile, having a molecular weight exceeding 30,000 and is a polysaccharide. The predominant sugars are glucose and mannose in 3:1 ratio. Preliminary studies of its action seem to indicate that the Alva fraction acts upon nonspecific response and could possibly stimulate the phagocyte activity of the peritoneal macrophagus.

Purification Of Active Substances Of Aloe Arborescens Miller & Their Biological & Pharmacological Activity
Saito, Hiroko
Dep. Pharm., Aichi Cancer Center
Phytother Res. (1993) 7 (Spec. Issue, Proceedings of the International Congress of Phytotherapy, 1991), S14-S19

The authors purified Aloctin A from Aloe arborescens Miller and defined its chem., biol. and pharmacol. activities. Aloctin A consists of two discrete bands, a and b with a combined S-S bond. Its mol. wt. for a is 7500 and the mol. wt. for b is 10,500. Aloctin A has many biol. and pharmacol. activities as follows: 1. hemagglutinating activity; 2. cytoagglutinating activity; 3. mitogenic activity of lymphocytes; 4. ppt. - forming reactivity with a2-macroglobulin; 5. complement C3 activating activity; 6. inhibition of heat-induced hemolysis of rat erythrocytes; 7. anti-tumor effect; 8. anti-inflammatory effect; 9. inhibition of gastric secretion and gastric lesions.