Tumor Inhibitors 114 Aloe Emodin: Antileukemic Principle Isolated From Rhamnus Frangula L
Kupchan SM; Karim A
Lloydia 39(4):223-4 1976 Jul-Aug

A systematic fractionation of an ethanol-water (1:1) extract of the seeds of Rhamnus frangula L., guided by assays for tumor-inhibitory activity, led to the isolation of Aloe emodin. This compound was found to show significant antileukemic activity against the P-388 lymphocytic leukemia in mice. A noteworthy vehicle-dependence of the testing results is reported. In the light of this vehicle-dependence, the re-examination of other anthraquinone derivatives is recommended.

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Cancer Research
Tizard I; Kemp M
Texas A&M

Research by the immunologist Ian Tizard, Ph.D. and virologist Maurice Kemp, Ph.D. from Texas A&M led to the discovery that Aloe mucopolysaccharide is taken into a special leukocyte, the macrophage, and this cell is stimulated to release messenger molecules called cytokines (interferons, interleukines, prostaglandins, tumor necrosis factor and stem-cell growth factors.) Tumors release a chemical that attracts blood circulation so that malignant cells have a supply to the tumor and it therefore dies. All of the immune modulating effects from Aloe contribute greatly to the prevention and healing of malignant cells.

Anticancer Effects Of Aloe On Sarcoma 180 In ICR Mouse & On Human Cancer Cell Lines
Jeong HY; Kim JH; Hwang SJ; Rhee DK
Coll. Pharm., Sung Kyun Kwan Univ.
Yakhak Hoeji 38 (3). 1994. 311-321

Anticancer effects of Aloe on sarcoma 180 in ICR mouse or human cancer cells were determined. Sarcoma 180 cells were inoculated subcutaneously into male ICR mouse to determine effect of Aloe on tumor growth, or inoculated intraperitoneally into male ICR mouse to determine effect of Aloe on life span prolongation, followed by oral administration of Aloe vera (10 mg/kg/day, 50 mg/kg/day) or Aloe arborescens (10 mg/kg/day, 100 mg/kg/day) once a day for 14 days. The administration of Aloe vera or Aloe arborescens did not suppress tumor growth. However the life span of ICR mouse was prolonged to 19% (P lt 0.05), 22% (P lt 0.05), and 32% (P lt 0.05) by administration of Aloe vera 10 mg/kg/day, Aloe vera 50 mg/kd/day, and Aloe arborescens 100 mg/kg/day, respectively. To determine anticancer effect of Aloe in vitro, Aloe extract was added to the culture of human gastric cancer cells (SNU-1) and colorectal cancer cells (SNU-C2A), and concentration of Aloe to inhibit cancer cell growth was determined using MTT (3 - (4, 5-dimethylthiazol-2-yl) -2, 5-diphenyltetrazolium bromide) cytotoxicity assay. High ID-50 values of Aloe vera and Aloe arborescens against gastric cancer cell line (SNU-1) and colorectal cancer cell line (SNU-C2A) suggest that Aloe gel does not have anticancer effect on these specific human cancer cells although high concentration of Aloe inhibited growth of human cancer cells significantly.

Antimutagen Of Aloe Plants
Nakasugi, Tohru; Komai, Koichiro
Res. Lab. Med, Prod. Plant Origin
Kinki Daigaku Nogakubu Kiyo (1994), 27, 47-54

An antimutagen from Aloe Arborescens Mill was isolated and identified. Methanol exts. from dried leaves of A. arborescens inhibited frameshift mutation induced by 3-amino-1-methyl-5H-pyrido [4, 3b] indole in Salmonella typhimurium TA98. The antimutagen isolated from the methanol exts. was identified as the anthraquinone Aloe-emodin. Aloe-emodin inhibited frameshift mutation by 60.3% at 0.1 mM/plate and 86.3% at 1.0 mM/plate whereas barbaloin, monoglucoside of Aloe-emodin, did not. Fresh A. aborescens leaves contained 1.17 ug/g (wet wt.) of Aloe-emodin. Aloe-emodin was also detected in A. ferox, A. vera, A. eru, and A. compacta by HPLC. These Aloe species may have substances that are useful for prevention of some forms of cancer.